项目来源

德国科学基金(DFG)

项目主持人

Robert Schneider

项目受资助机构

Ludwig-Maximilians-Universität München；

立项年度

2018

立项时间

未公开

项目编号

401883467

项目级别

国家级

研究期限

未知 / 未知

受资助金额

未知

学科

BIOCHEMISTRY

学科代码

未公开

基金类别

Collaborative Research Centres

关键词

未公开

参与者

未公开

参与机构

未公开

项目标书摘要：During the previous funding period,we made substantial contributions to decode the chemical code of histone and RNA modifications.We will now focus on the investigation of m6A in RNA and the manipulation of RNA modifications.Specifically,we will apply antibody independent m6A mapping approach in low input samples as well as epitranscriptomic editing.We will investigate the catalytic and non-catalytic functions of Mettl5 in mESCs and map m6A in rare cell populations during key cellular state transitions.Together,our in vitro and in vivo approaches will contribute to decipher the information encoded in chemical modifications of biomolecules.

Application Abstract: During the previous funding period,we made substantial contributions to decode the chemical code of histone and RNA modifications.We will now focus on the investigation of m6A in RNA and the manipulation of RNA modifications.Specifically,we will apply antibody independent m6A mapping approach in low input samples as well as epitranscriptomic editing.We will investigate the catalytic and non-catalytic functions of Mettl5 in mESCs and map m6A in rare cell populations during key cellular state transitions.Together,our in vitro and in vivo approaches will contribute to decipher the information encoded in chemical modifications of biomolecules.