Deciphering and repurposing bacterial one-component signaling.-Receptackle

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法(略)科(略)金(略)R(略)

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项目受资助机构

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立项年度

2(略)

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项目编号

A(略)2(略)E(略)2(略)

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国(略)

研究期限

未(略) (略)

受资助金额

5(略)0(略)0(略)

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B(略)h(略)e(略) (略)m(略)d(略)i(略)t

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基金类别

P(略)e(略)f(略)n(略)

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参与机构

C(略)C(略)r(略)a(略)n(略)d(略)a(略)c(略)c(略)S(略)n(略)i(略);(略) (略)t(略)n(略)o(略) (略)l(略)e(略)r(略) (略)e(略)f(略)e(略)S(略)n(略) (略)B(略)o(略) (略)u(略)r(略)

项目标书摘要:Su(略)mmary:Bac(略)ense and (略)myriad ch(略)physical (略)survive a(略)e.Signal (略)n in prok(略)dominated(略)ponent sy(略)ich the s(略)in is dir(略) to the D(略)domain,a (略)efficient(略)o transdu(略) signals (略)scription(略)ost one-c(略)stems are(略)c,and thu(略)onsive to(略)ues enter(略)l.Transme(略)ems,in co(略)ide versa(略)ficient b(略)een the e(略)tracellul(略)ents.Alth(略)lling key(略)pathways,(略)ulence ac(略) pathogen(略),these on(略)t 3%of th(略)-componen(略)nd are ha(略)dy.Despit(略)ndance an(略)ole in ba(略)naling an(略)city,the (略)mechanism(略),and dyna(略)brane-bou(略)onent sys(略) largely (略)The goal (略)ject is t(略)the mecha(略)olling si(略)ission he(略) in membr(略)ne-compon(略).We will (略)this know(略)prove the(略)g of modu(略)rs with w(略)tions in (略)We will c(略)expertise(略)ic biolog(略)l biology(略)sics to s(略)ly rebuil(略)e signali(略) in a sur(略),the non-(略)and genet(略)table bac(略)erichia c(略)er them t(略)their str(略)tion rela(略)s a model(略)will use (略) receptor(略)erived fr(略) one-comp(略)m recentl(略)d by our (略)igger gen(略)n in resp(略)feine.Thi(略) advance (略) understa(略)e-compone(略)and provi(略)rinciples(略)gineering(略)le progra(略)erial rec(略)ially nee(略)y applica(略)iagnosis,(略)on,and ba(略)ed therap(略)

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