Mechanisms of substrate selectivity of the nuclear RNA exosome complex
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德(略)基(略)F(略)
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C(略)e(略) (略)c(略)t
项目受资助机构
J(略)u(略)i(略)g(略)i(略)s(略)t(略)e(略),(略)h(略)e(略)-(略)l(略)e(略)d(略)e(略),(略)t(略)t(略)r(略)o(略)m(略)
项目编号
3(略)9(略)8
立项年度
2(略)
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未(略)
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未(略) (略)
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国(略)
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0(略)欧(略)
学科
G(略)r(略)G(略)t(略) (略) (略)c(略)n(略)G(略)m(略)i(略)g(略)
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I(略)p(略)e(略)J(略)o(略)e(略)r(略)G(略)p(略)
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未(略)
参与者
Dr. C(略)e(略) (略)c(略)t
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未(略)
项目标书摘要:Ce(略)evelopmen(略)ssful ada(略)a fluid e(略)require t(略)ated expr(略)housands (略)ordinated(略) RNA stab(略)an import(略)ring tran(略)ween diff(略)lar state(略)n integra(略) of many (略)onse path(略)to 5’exon(略)RNA exoso(略)is a majo(略) of RNA s(略) the cell(略)es many t(略) substrat(略)volved in(略)NA-proces(略) while sp(略)targeting(略)nd aberra(略) destruct(略)o acts in(略)criptiona(略)lation.Th(略)f the exo(略)thfully i(略) substrat(略)asis of i(略)ry functi(略)cell and (略) importan(略)ular well(略)egulation(略)lear RNA (略)ds to can(略)ease.The (略)l of my r(略)to define(略)isms invo(略) regulati(略)me select(略) the mole(略)ion and t(略)e of the (略) very wel(略)d,the fac(略)etermine (略)electivit(略) regulati(略)ctivity r(略)ly obscur(略)ect will (略) outstand(略)ns in the(略)can the n(略)surveilla(略)ry distin(略)ous trans(略) function(略)t factors(略)ed in exo(略)ing and h(略)rate sele(略)ated in r(略)external (略)ticular,u(略)arative p(略)pproach b(略) RNA inte(略)ture tech(略)t to iden(略)nding pro(略)direct RN(略)s towards(略)e,and aim(略)and how t(略)s determi(略)ificity o(略)me comple(略)ese prote(略)se their (略)and how d(略)ote RNA d(略)icular fo(略)esearch w(略)effect of(略)tress con(略)the subst(略)icity of (略) complex (略) dynamic (略)geting me(略)at help t(略)lular ada(略)cifically(略)e to DNA (略)damage tr(略)mplex gen(略)y program(略) be taken(略)igm for t(略)transcrip(略)post-tran(略) mechanis(略)lar stres(略)e.The ess(略)helicase (略)a vital r(略) process,(略)to unders(略)nction in(略)ether,the(略)will be f(略)for our u(略)g of how (略)riptional(略) shape ge(略)on progra(略)mote surv(略)termine c(略)
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